Cell signalling and bone remodelling
The skeleton as an endocrine relay organ - Part 1
Keywords:bone metabolism, cell signalling, skeletal remodelling
As knowledge on the signalling pathways involved in bone remodelling unfolds, maintenance of skeletal health and the management of skeletal diseases will increasingly focus on the manipulation of the autocrine, paracrine and endocrine mechanisms involved in the process. This overview is aimed at providing practitioners with an update on recent advances on cell signalling in bone remodelling and highlights the role of the skeleton in systemic metabolism.